Hiroyuki Yokote played an active role as the principal investigator in the attenuated smallpox vaccine LC16m8 project. He played a lead role in sharing the scientific and clinical research findings of the LC16m8 program at a number of scientific meetings, including the ASM Biodefense and Emerging Diseases Research Meeting since 2007. He also had been giving annual reports on the latest findings of the LC16m8 program at meetings of the WHO Advisory Committee on Variola Virus Research since 2007. Since 2004, He was a member of the Smallpox Vaccine Research Group which is an industry-government-academia research group in Japan and was established to research medical countermeasures against bioterrorism attacks with the smallpox virus based on recent findings. He joined the Chemo-Sero-Therapeutic Research Institute in 1981.